| 中文名稱 | 小牛致命性TRAIT A 46，皮膚角化不全症，鋅缺乏症 |
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| 英文名稱 | Lethal trait a 46, parakeratosis, zinc deficiency in calves |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 一漸進性並且有時致命的小牛疾病以滲出以及形成痂損傷為特色,和毛髮損失有關,特別是靠較下側肢,頭,和頸;會與延遲傷口癒合和肺炎相關.由於一體染色體隱性基因,導致一過多的鋅需求由於不能有效的從胃腸道吸收鋅.症狀一開始,有下痢通常最早臨床表露,是在二到六週齡.受影響的小牛也許有減少吮乳能力;很難彎曲他們的舌頭舔乳頭四周導致有用他們舌頭咀嚼和拉的動作,變平坦對乳頭嚥下乳汁.一場面出現相似於出現在銅缺乏會發生.報導在荷蘭牛,丹麥黑花牛,安哥斯牛,和短角牛種.藉由少的鋅含量和對治療反應來診斷.減少磷酸鹼含量使與那些鋅平等;這也許對於診斷有幫助.藉由鋅投與治療,然而會於當治療停止時故態復萌.如果小牛脫離治療,在四個月內就會死亡. |
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| 英文描述 | A progressive and sometimes fatal disease of calves characterized by oozing and crusting lesions associated with hair loss, especially of the lower limbs, head, and neck; there can be associated delayed wound healing and pneumonia. Due to an autosomal recessive gene, causing an excessive zinc requirement due to an inability to efficiently absorb zinc from the gastrointestinal tract. The onset of signs, with diarrhea usually the earliest clinical manifestion, is at 2-6 weeks of age. Affected calves might have diminished suckling ability; difficulty in curving their tongues around the nipple causes a chewing and pulling motion with their tongues flat against the nipple to ingest milk. A 'spectacle' appearance similar to that seen in copper deficiency can occur. Reported in Friesian, Danish Black Pied, Angus, and Shorthorn breeds. Dx by low zinc levels and response to treatment. Declines in alkaline phospatase levels parallel those of zinc; this might be useful for diagnosis. Treat by administration of zinc, however relapse occurs when therapy is stopped. If left untreated, the calf dies within 4 months. |
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